This work reports on a versatile procedure to address the insolubility in aqueous medium of hydrophobic antiviral drugs and the urgent need to apply this drug for treatment of viral infection such as Zika. The vesicles are directly composed of antiviral drug molecules with amphiphilic structures, which modulates the assembly mechanism. This new design is beneficial for different methods of drug delivery since it eliminates the need for the use of penetration enhancers such as surfactants, usually added to the nanovesicles suspensions.
Suzana Hamdan et al., University of Miami School of Medicine and Dr. JT Macdonald Foundation Biomedical Nanotechnology Institute, United States
ACS Omega 2022, 7, 25, 21359–21369